| Targeting postprandial glucose levels to attain glycemic control in Diabetes |
| HbA (1c) is the gold standard measure of glycaemic control but recent evidence suggests that postmeal hyperglycaemia also plays an important role in the etiology of diabetes-associated complications. |
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| Health issues in diabetic women – latest information |
| Diabetes has been associated with fertility issues, higher inflammatory stress & has been found to contribute to increased prevalence and incidence of atrial fibrillation… in women. |
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| Unique benefits of Voglibose in diabetics |
| This article discusses the unique benefits of Voglibose. Voglibose prevents pioglitazone-induced body weight gain in Type 2 diabetic patients, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients & reduces the progression of carotid intima-media thickness. |
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| Health issues in diabetic women – latest information |
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| Fertility issues in women with diabetes |
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Diabetes mellitus should be considered in the differential diagnosis of menstrual abnormalities and infertility. The reproductive period of diabetic women may be reduced due to delayed menarche and premature menopause. During the reproductive years, diabetes has been associated with menstrual abnormalities, such as oligomenorrhea and secondary amenorrhea.
It was found that better glycemic control and prevention of diabetic complications improves |
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| these irregularities and increases fertility rates close to those that are seen in the general population. Women with persistent menstrual abnormalities despite adequate treatment need to be approached by broader evaluation, which will include |
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The examination of the hypothalamic-pituitary-ovarian axis |
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The hormonal status |
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Presence of autoimmune thyroid disease |
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Antiovarian autoantibodies, and |
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Hyperandrogenism |
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| Livshits A et al. Fertility issues in women with diabetes. Womens Health (Lond Engl) 2009 Nov; 5(6):701-7. |
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| Higher inflammatory stress in women than in men with prediabetes and type 2 diabetes |
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| Saltevo J et al studied the gender differences in adiponectin and in low-grade inflammation, measured by high-sensitivity C-reactive protein (hs-CRP) and interleukin-1 receptor antagonist (IL-1RA), in individuals with normal glucose tolerance, prediabetes, and type 2 diabetes. |
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| Results: The eligible population included 1294 middle-aged individuals, and of these, 904 (406 men and 498 women) had complete data and were included in the analyses |
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Absolute adiponectin concentrations were significantly higher in women at all levels of glucose tolerance |
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The gender ratio (women to men) for adiponectin concentrations decreased linearly (P = 0.011) from normal glucose tolerance (1.61; 95% CI, 1.48-1.75) to prediabetes (1.57; 95% CI, 1.36-1.83) and diabetes (1.16; 95% CI, 0.87-1.53). |
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Among patients with prediabetes or diabetes, women had significantly higher concentrations than did men for hs-CRP (for prediabetes, 2.0 vs 1.5 mg/L; ratio, 1.39; 95% CI, 1.04-1.85) and IL-1RA (for prediabetes, 255 vs 178 pg/mL; ratio, 1.43; 95% CI, 1.121.83). |
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The gender ratios (women to men) increased linearly from normal glucose tolerance to prediabetes and type 2 diabetes for both hs-CRP (P = 0.019) and IL-1RA (P = 0.013). |
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Adiponectin concentrations in women decreased relatively more compared with men across
individuals with normal glucose tolerance, prediabetes, and type 2 diabetes, whereas inflammatory markers increased relatively more in women.
Higher inflammatory stress in women than in men with prediabetes and type 2 diabetes may explain their relatively higher cardiovascular disease risk. |
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| Independent contribution of diabetes to increased prevalence and incidence of atrial fibrillation in women |
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Nichols GA et al. compared the baseline prevalence of atrial fibrillation and then followed patients without atrial fibrillation to compare atrial fibrillation incidence while controlling for known risk factors.
Results: Atrial fibrillation prevalence was significantly greater among patients with diabetes (3.6 vs. 2.5%, P < 0.0001). Over a mean follow-up of 7.2 +/- 2.8 years, diabetic patients without atrial fibrillation at baseline developed atrial fibrillation at an age- and sex-adjusted rate of 9.1 per 1,000 person-years (95% CI 8.6-9.7) compared with a rate of 6.6 (6.2-7.1) among nondiabetic patients. |
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After full adjustment for other risk factors, diabetes was associated with a 26% increased risk of atrial fibrillation among women (hazard ratio 1.26 [95% CI 1.08-1.46]), but diabetes was not a statistically significant factor among men (1.09 [0.96-1.24]). diabetes was an independent determinant of atrial fibrillation prevalence but predicted incidence only among women.
Nichols GA et al. Diabetes Care. 2009 Oct;32(10):1851-6. |
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