BRITE CREAM

Composition
Hydroquinone ………………………2%
Octyl Methoxy Cinnamate…………5%
Oxybenzone…………………………3%

Presentation
Tube of 20 gms.

Mechanism of action
Hydroquinone acts by inhibiting the enzymatic oxidation of tyrosine to 3,4-dihydoxyphenylalanine (DOPA) and subsequently to melanin thereby producing a reversible depigmentation of the skin.
Exposure to sunlight or ultraviolet light will cause repigmentation, which may be prevented by sun blocking agents.
Sunscreen Agents - Octyl Methoxy Cinnamate & Oxybenzone

Sun Screen agents are incorporated in Brite Cream keeping in line with the Hydroquinone therapy.
Sunscreen agents are rated for their "Sun Protective Factor" (SPF).
SPF can be defined as the rate of the time required to produce sunburn erythema with and without sunscreen application.
Therefore SPF can be given as follows:
UV energy required to produce a minimal erythemal dose (MED) on protected skin

UV energy required to produce a MED on unprotected skin

Sunscreen agents with SPF 8 -15 provide maximum protection. The SPF value of the sunscreen agents incorporated in Brite Cream is 10+, that provides protection against the ultraviolet A (UVA) and Ultraviolet B(UVB) sun rays –

Indications
> Melasma
> Chloasma
> Acne Marks
> Freckles
> Lentigene
> Post Inflammatory Hyperpigmentation

Dosage & Administration
Brite Cream should be applied to the affected area and rubbed in twice daily or as directed by the physician.

Adverse Effects
Dryness and fissuring of paranasal and infraorbital areas; erythema; stinging; irritation; sensitisation and contact dermatitis in susceptible individuals.

Overdosage
There have been no systemic reactions from the use of topical hydroquinone. However, limit treatment to relatively small areas of the body at one time, since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment.